Spreading of molecular mechanical perturbations on linear filaments

摘要: Abstract Global changes in the state of spatially distributed systems can often be traced back to events resulting from local interactions. Whether results interactions grow into global changes, however, depends (i) on system geometry and (ii) spatial spreading outcomes Here, we investigate how different behaviors determine their impact one-dimensional size. In particular, combine vitro experiments where groups myosin motors propel actin filaments, single-molecule resolution simulations these experiments, an abstracted spin chain model. All three approaches lead same two conclusions. First, that become long-term stable only after they have spread full size more smaller systems. Second, are relatively upon initial occurrence then larger Our work provides highly specific predictions for future resolve actin-myosin-crosslinker along filaments. Also, conclusions our should generally apply local-to-global finite, geometries. Significance Statement We address fundamental question To this end, reconstituted molecular contractile machinery muscle, which is organized around linear filaments length drives forward sliding. addition, use detailed follow mechanically interacting molecules individually. Lastly, used a abstract theoretical physics model, transfers all with give results: persist once cover whole affect strongly; even before strongly.