MiR-301a is activated by the Wnt/β-catenin pathway and promotes glioma cell invasion by suppressing SEPT7

摘要: Background miR-301a is frequently dysregulated and specific to human tumors, playing a critical role in tumorigenesis; however, the exact functions regulatory mechanisms of glioma cells remain largely unknown. Herein, we show that activated by Wnt/β-catenin pathway promoted invasion directly targeting SEPT7. Methods Biochemical, luciferase reporter, hromatin immunoprecipitation PCR assays characterized function invasion. Results Initially, detected expression tissues identified had increased, with ascending grades tumor. Furthermore, high levels were associated poorer prognosis patients. It important note Wnt/β-catenin/TCF4 enhanced binding promoter region. To determine oncogenic glioma, SEPT7 was supported as direct target gene. In addition, repressed expression, which dependent on cells. Finally, then inhibiting vitro vivo. Conclusions Our findings revealed mechanism action for tumor cell Moreover, Wnt/miR-301a/SEPT7 signaling axis might be novel treating glioma.