Poly(Glycerol Sebacate) Elastomer: A Novel Material for Mechanically Loaded Bone Regeneration

摘要: The selection criteria for potential bone engineering scaffolds are based chiefly on their relative mechanical comparability to mature bone. In this study, we challenge notion by obtaining full regeneration of a rabbit ulna critical size defect employing the elastomeric polymer, poly(glycerol sebacate) (PGS). We tested facilitated PGS alone, in combination with hydroxyapatite particles, or seeded marrow stromal cells. investigated quantity and quality regenerated histologically, microcomputed tomography four-point bending flexural testing at 8 weeks postimplantation. conclude that relatively lower stiffness biocompatible elastomer allows load-transducing milieu which osteogenesis, matrix deposition, eventual maturation can take place. This study's results suggest is an auspicious osteoconductive material bony defects. These call innova...