Impact of physiological levels of chenodeoxycholic acid supplementation on intestinal and hepatic bile acid and cholesterol metabolism in Cyp7a1-deficient mice.

作者: Ryan D. Jones , Adam M. Lopez , Ernest Y. Tong , Kenneth S. Posey , Jen-Chieh Chuang

DOI: 10.1016/J.STEROIDS.2014.11.002

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摘要: Abstract Mice deficient in cholesterol 7α-hydroxylase (Cyp7a1) have a diminished bile acid pool (BAP) and therefore represent useful model for investigating the metabolic effects of restoring with specific BA. Previously we carried out such studies Cyp7a1−/− mice fed physiological levels cholic (CA) achieved BAP restoration, along an increased CA enrichment, at dietary level just 0.03% (w/w). Here demonstrate that chenodeoxycholic (CDCA) 0.06% (w/w), was restored to normal size became substantially enriched muricholic (MCA) (>70%), leaving combined contribution CDCA be

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