High-performance liquid chromatographic determination of sotalol in plasma. I. Application to the disposition of sotalol enantiomers in humans.
作者： Benedetta C. Sallustio , Raymond G. Morris , John D. Horowitz
DOI: 10.1016/0378-4347(92)80206-6
关键词:
摘要: Two high-performance liquid chromatographic analytical methods have been developed for the measurement of dl-sotalol or d-sotalol and l-sotalol in plasma, using dl-atenolol as internal standard. Quantitation was carried out, following solid-phase extraction, on a 5-microns C18 reversed-phase column, with mobile phase containing acetonitrile, ion-pairing reagent distilled water, ultraviolet detection at 235 nm. based derivatisation chiral agent S-(-)-alpha-methylbenzyl isocyanate, followed by separation 3-microns methanol, glacial acetic acid fluorimetric 220 nm excitation 300 emission. A preliminary application latter method suggests that disposition sotalol humans is not enantioselective.
elsevier.com
sci-hub.se 参考文章(22)
T Walle, E E Bagwell, J G Webb, T E Gaffney, Stereoselective uptake of atenolol into storage granules isolated from PC12 cells. Journal of Pharmacology and Experimental Therapeutics. ,vol. 249, pp. 476- 482 ,(1989)
Poe-Hirr Hsyu, Kathleen M. Giacomini, High Performance Liquid Chromatographic Determination of the Enantiomers of β-Adrenoceptor Blocking Agents in Biological Fluids I: Studies with Pindolol Journal of Pharmaceutical Sciences. ,vol. 75, pp. 601- 605 ,(1986) , 10.1002/JPS.2600750616
Bramah N. Singh, Koonlawee Nademanee, Sotalol: a beta blocker with unique antiarrhythmic properties. American Heart Journal. ,vol. 114, pp. 121- 139 ,(1987) , 10.1016/0002-8703(87)90316-4
Ioannis Rizos, Jochen Senges, Rolf Jauernig, Wolfgang Lengfelder, Ellen Czygan, Johannes Brachmann, Wolfgang Kübler, Differential effects of sotalol and metoprolol on induction of paroxysmal supraventricular tachycardia The American Journal of Cardiology. ,vol. 53, pp. 1022- 1027 ,(1984) , 10.1016/0002-9149(84)90630-1
Bramah N. Singh, Prakash Deedwania, Koonlawee Nademanee, Alan Ward, Eugene M. Sorkin, Sotalol. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use. Drugs. ,vol. 34, pp. 311- 349 ,(1987) , 10.2165/00003495-198734030-00002
Lawrence S Olanoff, Thomas Walle, U Kristina Walle, T Douglas Cowart, Thomas E Gaffney, Stereoselective clearance and distribution of intravenous propranolol Clinical Pharmacology & Therapeutics. ,vol. 35, pp. 755- 761 ,(1984) , 10.1038/CLPT.1984.107
GD Johnston, MB Finch, JA McNeill, RG Shanks, A comparison of the cardiovascular effects of (+)-sotalol and (+/-)-sotalol following intravenous administration in normal volunteers. British Journal of Clinical Pharmacology. ,vol. 20, pp. 507- 510 ,(1985) , 10.1111/J.1365-2125.1985.TB05109.X
Rebecca A Boyd, Shu K Chin, Oluta Don-Pedro, Roger L Williams, Kathleen M Giacomini, The pharmacokinetics of the enantiomers of atenolol. Clinical Pharmacology & Therapeutics. ,vol. 45, pp. 403- 410 ,(1989) , 10.1038/CLPT.1989.47
Rinya Kato, Nobuo Ikeda, Steven M. Yabek, Ramaswamy Kannan, Bramah N. Singh, Electrophysiologic effects of the levo- and dextrorotatory isomers of sotalol in isolated cardiac muscle and their in vivo pharmacokinetics. Journal of the American College of Cardiology. ,vol. 7, pp. 116- 125 ,(1986) , 10.1016/S0735-1097(86)80268-6
P J Neuvonen, E Elonen, A Tanskanen, J Tuomilehto, Sotalol prolongation of the QTC interval in hypertensive patients Clinical Pharmacology & Therapeutics. ,vol. 32, pp. 25- 32 ,(1982) , 10.1038/CLPT.1982.122