Under-reporting of adverse drug reactions : a systematic review.

摘要: The purpose of this review was to estimate the extent under-reporting adverse drug reactions (ADRs) spontaneous reporting systems and investigate whether there are differences between different types ADRs. A systematic literature search carried out identify studies providing a numerical under-reporting. Studies were included regardless methodology used or setting, e.g. hospital versus general practice. Estimates either extracted directly from published study calculated data. These expressed as percentage ADRs detected intensive data collection that not reported relevant local, regional national systems. median rate across all within subcategories using methods settings. In total, 37 wide variety surveillance identified 12 countries. generated 43 estimates 94% (interquartile range 82-98%). There no significant difference in rates for practice hospital-based studies. Five ten provided evidence higher compared with more serious severe (95% 80%, respectively). comparison, five eight remained high (95%). lower 19 investigating specific serious/severe ADR-drug combinations but still at 85%. This provides widespread including Further work is required assess impact on public health decisions effects initiatives improve such internet reporting, pharmacist/nurse direct patient well improved education training healthcare professionals.