Pharmacotherapy to Enhance Cognitive and Motor Recovery Following Stroke

摘要: Stroke is a leading cause of disability among older adults and more than half stroke survivors have some residual neurological impairment. Traditionally, managing the aftermath has been by implementation several physical language therapy modalities. The limitations these rehabilitation efforts sparked an interest in finding other ways to enhance recovery. Some novel approaches included pharmacological interventions, cell-derived treatments, cortical magnetic stimulation. Mounting evidence over last 2 decades suggests that manipulations may potential modulate practice-dependent neuroplasticity potentially improve recovery after stroke. Multiple agents with different mechanisms action evaluated, showing conflicting results. studies suggest promise, yet quality available suboptimal overall, most being underpowered. So far, promising include antidepressants for motor acetylcholinesterase inhibitors memantine aphasia. However, large, well-designed clinical trials are needed address shortcomings data before any agent can be recommended routine use as part standard algorithm management.