Pre-diagnostic colonoscopies reduce cancer mortality - results from linked population-based data in South Australia

摘要: To investigate the association between pre-diagnostic colonoscopy and colorectal cancer mortality in South Australia. Colonoscopy histories were obtained for patients diagnosed 2003–2013 using linked Medical Benefits Schedule (MBS) claims, hospital-inpatient cancer-registry data. included year of colonoscopy, numbers examinations, time from first to diagnosis. Histories multiple exposures colonoscopies, greater than a initial diagnosis, regarded as indicators screening or surveillance activity. Colonoscopies occurring within one diagnosis more likely be response symptoms those > 1 year before Associations history post-diagnostic survival analysed sub-hazard ratios (SHRs) competing risk regression adjusted socio-demographic characteristics. Having was associated with an unadjusted reduction death 17% (SHR: 0.83, 95% CI 0.78–0.89). After adjusting period sociodemographic characteristics, reduced by examination; 27% two examinations; 45% three examinations. Those over study window when compared less year, had lower this analysis. These reductions substantially eliminated also advanced stage. Pre-diagnostic so, colonoscopies longer post This largely explained stage at