Carcinogenesi: La sequenza adenoma-carcinoma e i pathway alternativi
作者： Mauro Risio
DOI: 10.1007/978-88-470-1067-3_2
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摘要: La carcinogenesi e un processo multifasico multifattoriale che si sviluppa attraverso una sequenza di eventi biologici intermedi tra l’esposizione ad uno o piu carcinogeni l’insorgenza neoplasia invasiva. Nei primissimi stadi, l’innesco della intestinale puo essere evidente nella mucosa priva alterazioni istologiche anche in completa assenza lesioni neoplastiche endoscopicamente rilevabili. Si tratta cellulari molecolari associate alla iniziazione/promozione neoplastica, conseguenti all’interazione fattori ambientali microambientali ed epitelio intestinale, possono evidenziate e, alcuni casi, misurate aree molto estese [1].
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