The 26 S proteasome: from basic mechanisms to drug targeting.

摘要: The regulated degradation of proteins within eukaryotes and bacterial cells is catalyzed primarily by large multimeric proteases in ATP-dependent manner. In eukaryotes, the 26 S proteasome essential for rapid destruction key regulatory proteins, such as cell cycle regulators transcription factors, whose fast tuned elimination necessary proper control fundamental processes they regulate. addition, responsible quality eliminating defective from cytosol endoplasmic reticulum. These can be misfolded nascent prematurely terminated polypeptides, or that fail to assemble into complexes. diverse activities its central role apoptosis have made an important target drug development, particular combat malignancies.