Smaller Prostate Volume is Associated with Adverse Pathological Features and Biochemical Recurrence after Radical Prostatectomy

摘要: Introduction: The relationship between prostate cancer (PCa) and benign prostatic hyperplasia is unclear. Reduction in androgenicity lower intraprostatic growth factor concentrations smaller prostates may serve a more ideal environment for the development of aggressive tumors. We determined if volume was associated with adverse pathological features, tumor volume, biochemical recurrence (BCR) men undergoing radical prostatectomy (RP) PCa. Materials Methods: retrospectively identified 192 who underwent RP at our institution PCa from 2010 to 2016 years. Prostate based on specimen weight, cumulative calculated. Means were compared one-way ANOVA test proportions Chi-square analysis. Multivariate logistic regression performed determine independent predictors BCR after RP. Results: Patients >60 g less likely have high-risk (Gleason grade group >4) (7.1% vs. 13.4%; P = 0.042), node-positive disease 13.4%, (10.7% 25.0%, 0.002) surgery. Linear showed an inverse (R 0.267; 30 (odds ratio [OR]: 0.21, 95% confidence interval [CI]: 0.09–0.88; 0.015) (OR: 0.14, CI: 0.03–0.74; reduced mean follow-up 24 months.Conclusions: Smaller increased higher incidence disease, rates BCR. should be considered as prognostic feature when counseling patients both elevated prostate-specific antigen newly diagnosed