The reno-protective effect of aqueous extract of Carum carvi (black zeera) seeds in streptozotocin induced diabetic nephropathy in rodents

摘要: To assess the effect of aqueous extract Carum carvi seeds in experimentally induced diabetic nephropathy (DN) rodents, we studied 48 adult male Wistar rats divided into 4 groups: normal controls (group A), diabetes positive control B), and experimental (groups C D). They received as a renoprotective agent. Rats having fasting blood glucose levels over 280 mg/dL were included this study. Group STZ (60 mg/kg) at 30 mg/kg body weights. On other hand group D 60 weight. Blood samples collected on th day, kidneys also extracted for examination. The showed variable increase serum glucose, urea, creatinine, total urinary protein microalbuminuric levels. Body weight decreased urine volume increased groups. dose these parameters rats. hand, significantly biochemical parameters. morphological examination no changes whereas moderate changes. constituents, especially flavonoids carvone have strong anti-oxidant activity, which provides reno-protection against its complications. In conclusion, high dia-betic