Prognostic Impact of Bcl-2 Depends on Tumor Histology and Expression of MALAT-1 lncRNA in Non–Small-Cell Lung Cancer
作者： Lars Henning Schmidt , Dennis Görlich , Tilmann Spieker , Christian Rohde , Martin Schuler
DOI: 10.1097/JTO.0000000000000243
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摘要: Introduction Apoptosis is a crucial pathway in tumor growth and metastatic development. Apoptotic proteins regulate the underlying molecular cascades are thought to modulate response chemotherapy radiation. However, prognostic value of expression apoptosis regulators localized non–small-cell lung cancer (NSCLC) still unclear. Methods We investigated protein Bcl-2, Bcl-xl, Mcl-1, pp32/PHAPI, lncRNA MALAT-1 samples from 383 NSCLC patients (median age: 65.6 years; 77.5% male; paraffin-embedded tissue microarrays). For statistical analysis correlation tests, Log rank tests Cox proportional hazard models were applied. Results Tumor histology was significantly associated with Bcl-xl Mcl-1 (all p = 0.012). non-adenocarcinoma histology, Bcl-2 increased overall survival ( 0.036). Besides impact also found depend on expression. Gene A549 adenocarcinoma cells differential demonstrated an influence its interacting proteins. Conclusions specifically superior prognosis NSCLC. An interaction revealed, which merits further investigation for risk prediction resectable patients.
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