Pharmacologic and behavioral effects on arrhythmias that immediately follow abrupt coronary occlusion: A canine model of sudden coronary death☆

摘要: Abstract We have developed and studied a chronically instrumented canine model in which occlusion of major coronary artery by an implanted balloon occluder promptly leads to arrhythmias that are reasonably reproducible on successive occlusions. Dogs were while conscious, the electrocardiogram electrograms from ischemic nonischemic ventricular epicardium recorded. Either left anterior descending or circumflex was occluded for up 5.5 minutes. Experiments performed carefully controlled environment at intervals sufficient full recovery between The occurred single multiple premature depolarizations, runs depolarizations fibrillation. measured time onset arrhythmia (latency) severity (grade). Latency increased with occlusions same until no during In this state, addition behavioral stress usually led recurrence arrhythmia. Stress decreased latency ( P