Buffered end-tidal (BET) sampling—a novel method for real-time breath-gas analysis
作者： Jens Herbig , Thorsten Titzmann , Jonathan Beauchamp , Ingrid Kohl , Armin Hansel
DOI: 10.1088/1752-7155/2/3/037008
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摘要: We present a novel method for real-time breath-gas analysis using mass-spectrometric techniques: buffered end-tidal (BET) on-line sampling. BET has several advantages over conventional direct sampling where the subject inhales and exhales through tube. In our approach, single exhalation is administered tailored tube in which fraction of sample buffered. This increases time by an order magnitude to seconds, improving signal quality reducing total measurement per test subject. Furthermore, only one minute required can otherwise maintain normal breathing pattern, thereby risk hyperventilation. To validate new we conducted comparative measurements with proton-transfer-reaction mass spectrometry. find excellent agreement measured acetone acetonitrile concentrations. High variability observed breath-by-breath isoprene concentrations attributed differences depth influences hyperventilation on
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