Dosis de metadona y su relación con calidad de vida, satisfacción, psicopatología, rendimiento cognitivo y consumo adicional de sustancias no prescritas Methadone dosage and its relationship to quality of life, satisfaction, psychopathology, cognitive performance and additional consumption of non-prescribed drugs

摘要: The effectiveness of methadone maintenance treatment is beyond any doubt, but there remains some incertitude about the appropriate and effective dosage objectives that should be achieved by this therapy. Some authors maintain only doses higher than 50-60 mg/day ought to considered effective, since these block all opioid receptors. But others propose use adjusted needs patient, based on their recovery process. Quality life, satisfaction with treatment, psychopathological symptoms, cognitive performance additional intake illegal unprescribed drugs were evaluated in a representative sample patients treated agonists Addiction Institute Madrid (N = 1898, n 450) Junta de Extremadura 100, 65). results revealed negative relationship between dose quality symptoms performance. Satisfaction negotiated together doctor was very high, regardless dose. To establish hypothetical causal dependencies among studied variables structural equation modelling performed. reject need for high if not required highlight benefits other psychosocial interventions lead