Systematic review: the hepatotoxicity of non-steroidal anti-inflammatory drugs.

摘要: SUMMARY 1 Background: Non-steroidal anti-inflammatory drugs have been implicated in reports of liver injury. However, the precise risk non-steroidal for this rare complication is unknown. Aim: To review systematically published literature ofpopulation-basedepidemiological studies reportingthe incidence or comparative antiinflammatory injury resulting clinically significant events, defined as hospitalization death. Data extraction: Duplicate extraction methodological quality, design, source, population, years studied, particular definitions, patient counts and follow-up, adjustment confounders. Results: Seven articles met inclusion criteria. The current drug users compared with past ranged from 1.2 to 1.7, but none was statistically significant. 3.1 23.4/100 000 patient-years use nonsteroidal drugs, an excess 4.8‐8.6/100 exposure. There were zero deaths associated over 396 392 cumulative Conclusion: These findings allow possibility a small increase relevant hepatotoxicity use, do not document that such occurs.