作者: Albert Adam , Charles Blais , François Marceau
DOI: 10.1007/978-3-0348-7579-0_9
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摘要: Similar to the renin-angiotensin system, kallikrein-kinin system (KKS) is a cascade of activators (kallikreins) which hydrolyse substrates (kininogens) release vasoactive peptides (kinins). The nature various constituents and their properties have been extensively reviewed recently [1]. Low high molecular weight kininogens (LK HK, respectively) are multidomained multifunctional glycoproteins exert regulatory functions at sites local inflammation. They kinins powerful proinflammatory also inhibit, least in vitro, lysosomal thiol proteases released during tissue injury. Through its light chain, HK cofactor activation Hageman factor by contact with negatively charged surface (e.g., damaged myocardium) leads formation clot.