The contribution of angiotensin-converting enzyme (ACE) to the metabolism of kinins (bradykinin and des-Arg9-bradykinin) and effect of ACE inhibitors on their in vitro and in vivo metabolism

作者: Albert Adam , Charles Blais , François Marceau

DOI: 10.1007/978-3-0348-7579-0_9

关键词:

摘要: Similar to the renin-angiotensin system, kallikrein-kinin system (KKS) is a cascade of activators (kallikreins) which hydrolyse substrates (kininogens) release vasoactive peptides (kinins). The nature various constituents and their properties have been extensively reviewed recently [1]. Low high molecular weight kininogens (LK HK, respectively) are multidomained multifunctional glycoproteins exert regulatory functions at sites local inflammation. They kinins powerful proinflammatory also inhibit, least in vitro, lysosomal thiol proteases released during tissue injury. Through its light chain, HK cofactor activation Hageman factor by contact with negatively charged surface (e.g., damaged myocardium) leads formation clot.

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