Cytokine imbalance at materno-embryonic interface as a potential immune mechanism for recurrent pregnancy loss.

摘要: Recurrent pregnancy loss (RPL) is a prominent reproductive disease that distresses about 2%-5% of couples. RPL the two or more successive spontaneous pregnancies prior to 20th week embryo development. The commencement necessitates implantation into responsive maternal decidua synchronized with process placentation, decidual and myometrial trophoblast incursion as well refashioning spiral blood arteries uterus. collapse any processes fundamental for success may result an array problems including loss. Endometrium human female manufactures extensive range cytokines during proliferative secretory stage menstrual cycle. These endometrial are thought major players making uterus ready placental development pregnancy. Decidual regulate invasion remodeling take part in immune suppression accomplish Deterrence rejection needs regulated milieu, which takes place essentially at embryo-maternal interface tissues reasons remain anonymous large number cases lead difficulties management severe trauma Cytokine modulatory therapies have been shown promising preventing RPL. Further study novel factors wanted establish effective treatment protocols. present aims review outcome cytokine breach materno-embryonic efficacy