Functional Loss in the Magnocellular and Parvocellular Pathways in Patients with Optic Neuritis
作者： Dingcai Cao , Andrew J. Zele , Joel Pokorny , David Y. Lee , Leonard V. Messner
DOI: 10.1167/IOVS.11-7644
关键词:
摘要: PURPOSE. To evaluate contrast threshold and gain in patients with optic neuritis under conditions designed to favor mediation by either the inferred magnocellular (MC) or parvocellular (PC) pathway. METHODS. Achromatic chromatic discrimination was measured 11 unilateral bilateral 18 age-matched controls normal vision, using achromatic steady- pulsed-pedestal paradigms bias performance toward MC PC pathway, respectively. In addition, L-M at equiluminance evaluated steady-pedestal paradigm. A physiologically plausible model could describe data parameters accounting for sensitivity The fitted from eye affected were compared those generalized estimation equation (GEE) models that can account within-subject correlations. RESULTS. Compared eyes, eyes had significantly higher saturation when both paradigm (GEE: [SE] 0.35 [0.06]; P 0.001) ( 0.18 [0.08]; 0.015), suggesting pathway is reduced; also reduced absolute 0.12 [0.04]; 0.005). CONCLUSIONS. Optic produced large losses mediated clinical framework presented interpreting loss stimuli terms of retinal postretinogeniculate loci contributions detection discrimination. (Invest Ophthalmol Vis Sci. 2011;52:8900‐8907) DOI:10.1167/ iovs.11-7644
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