Serum Ferritin as a Component of the Insulin Resistance Syndrome

摘要: OBJECTIVE In epidemiological studies, serum ferritin was the second-strongest determinant of blood glucose (after BMI) in regression models and third-strongest insulin BMI age). Its concentration also correlated positively with plasma triglycerides apolipoprotein B concentrations, negatively HDL 2 cholesterol. We hypothesized that could be a marker resistance. RESEARCH DESIGN AND METHODS Oral tolerance sensitivity (S I , minimal model method) were prospectively evaluated 36 healthy subjects. The relationship between metabolic control (as measured by HbA 1c levels) studied 76 consecutive NIDDM patients. RESULTS subjects, log-transformed (LOGFER) basal ( r = 0.44, P 0.007), but not BMI, age, systolic or diastolic pressure, total cholesterol, VLDL triglycerides, insulin, (all NS). Identical results obtained when two lowest quartiles separately. However, highest quartiles, LOGFER (0.50, 0.02), pressure 0.8, 0.57, 0.01), cholesterol 0.48, 0.03), 3 subtractions −0.68, −0.76, −0.55, 0.001. 0.60, 0.006), /HDL quotient −0.71, 0.001), 0.65, 0.004), uric acid 0.51, 0.38, 0.15). After adjusting for only correlations 0.7, 0.002) −0.63, 0.01) remained significant. Strong area under curve during oral test (Pearson9s 0.73, 0.001) S 1 which significant after controlling observed. (β −0.44, −0.52, 0.004) constituted independent predictors multivariate analysis (R 0.68). outpatients, 0.03) independently predicted value 0.40) multiple linear analysis. CONCLUSIONS among quotient, curve, suggest resistance syndrome. Serum may an poor diabetic patient.