MULTI-TARGETED, TUNABLE, SUSTAINED DELIVERY OF PAYLOADS TO CHARGED AVASCULAR TISSUES

作者: Krishnan Yamini , Grodzinsky Alan

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摘要: Provided here in are methods and compositions for delivering a payload molecule to charged avascular tissue or partially vascularized subject, the method including administering subject need thereof an effective amount of carrier, wherein carrier is cationic and/or has surface charge distribution such that about 40% greater continuous region positively charged, linked with molecule, deliver tissue.

参考文章(3)
James Joseph Cronican, Brian R. Mcnaughton, David R. Liu, David B. Thompson, Supercharged proteins for cell penetration ,(2009)
Alexander Garruss, George M. Church, Marc Guell, Jameson K. Rogers, Methods and systems of cell-free enzyme discovery and optimization ,(2017)
Yamini Krishnan, Holly A. Rees, Christina P. Rossitto, Si-Eun Kim, Han-Hwa K. Hung, Eliot H. Frank, Bradley D. Olsen, David R. Liu, Paula T. Hammond, Alan J. Grodzinsky, Green fluorescent proteins engineered for cartilage-targeted drug delivery: Insights for transport into highly charged avascular tissues Biomaterials. ,vol. 183, pp. 218- 233 ,(2018) , 10.1016/J.BIOMATERIALS.2018.08.050