Microtubule dynamics and morphogenesis in Paramecium

摘要: Summary In Paramecium, the deployment of an acetylated microtubular network is restricted to a part ventral cell surface, A-paratene zone. Upon division, this depolymerizes; it reassembled only after separation. Convergent evidences suggest that one primary signals for cortical morphogenesis could be Ca2+ wave. Correlatively, calcium ions inhibit enzyme which acetylates microtubules and prevent microtubule stabilization by associated proteins (MAPs). All these data have been gathered into model shows how transient signal (the wave) may converted permanent morphological modification assembly state A-paratene-associated microtubules. model, biochemical switches between acetylation depolymerization pathways acting on stabilized occur beyond assembly/disassembly step unstabilized Accordingly, inhibitory effect has triggering action dynamics whereas its indirect MAPs irrelevant in respect. This also interprets why resists nocodazole but not cold treatment. From analysis, we various control mechanisms act at level each would make both origin biological significance diversity regulative.