Effect of sofosbuvir and ribavirin treatment on peripheral and hepatic lipid metabolism in chronic hepatitis C virus, genotype 1-infected patients

摘要: Hepatitis C virus (HCV) modulates intrahepatic cholesterol biosynthetic pathways to promote viral replication. Chronic HCV infection is associated with altered metabolism, including dyslipidemia and insulin resistance, which contributes disease progression influences response therapy. To further understand the impact of on host we examined changes in serum lipid profiles expression lipid-related genes during interferon (IFN)-free treatment chronic HCV, genotype-1 sofosbuvir ribavirin (RBV), explored associations outcome. Serum lipids (total cholesterol, low density lipoprotein (LDL), high (HDL), triglycerides) hemoglobin A1C (HbA1C) were measured treatment, while gene was assessed using paired pre- end (EOT) liver biopsies from 8 patients (n=7 sustained virologic (SVR), n=1 relapse) unpaired EOT 25 (n= 17 SVR, n=8 relapse). LDL concentration particle size increased early therapy, triglyceride very (VLDL) decreased concomitantly, irrespective While regardless outcome, average lower at baseline post-treatment who relapsed. Analysis revealed transport, assembly, signaling. In biopsies, fatty acid metabolism transport experienced relapse. Conclusion Clearance an IFN-free antiviral regimen results rapid peripheral metabolic pathways, implicating a direct effect replication homeostasis.