microRNA(interference) networks are embedded in the gene regulatory networks.

摘要: microRNAs (miRNAs) are a class of endogenous 22-25nt single-stranded RNA molecules that regulate gene expression post-transcriptionally. They highly conserved among species with distinct temporal and spatial patterns expression, each them potentially interacting hundreds messenger RNAs. Since miRNAs, like transcription factors (TFs), trans-acting interact cis-regulatory elements, they generate complex combinatorial code. Moreover, as TFs genes containing binding sites for have high probability being targeted by the basic interplay miRNA/TF renders miRNAs key components regulatory networks. Several biological processes, including diseases such cancer, been causatively associated to disturbances miRNAs/TF both in vitro vivo. These aspects, cumulatively, indicate crucial role determining cellular behaviour, highlighting small ...