Synthesis of functionalized cage propellanes and D3-Trishomocubanes via the ring-closing metathesis and acid-promoted rearrangement
作者： Sambasivarao Kotha , Subba Rao Cheekatla
DOI: 10.1016/J.TET.2018.11.027
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摘要: Abstract Several functionalized cage propellanes and D3-trishomocubanes containing spiro linkage have been reported starting with commercially available materials such as 1,4-hydroquinone dicyclopentadiene. In this regard, Claisen rearrangement, Diels–Alder reaction (DA), ring-closing metathesis (RCM) acid-promoted rearrangement used key steps. The strategies described here, opens up new opportunities to assemble intricate systems that are difficult construct by conventional methods. Carbocation intermediates generated during the process play a prominent role in designing unusual systems. One of rearranged compound's structure was unambiguously established single crystal X-ray diffraction studies.
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