Functional heterotypic interactions between astrocyte and oligodendrocyte connexins.

摘要: Human genetic diseases and mouse knockouts illustrate that the maintenance of central nervous system myelin requires connexin expression by both astrocytes oligodendrocytes. Because these cell types express nonoverlapping sets connexins, intercellular channels formed between them must be asymmetric with regard to content, defined as heterotypic. Here, we show oligodendrocyte Cx47 can form heterotypic astrocyte Cx43 or Cx30 but not Cx26, whereas Cx32 functionally interact Cx26 Cx43. Thus, many four could