Vanishing honey bees: Is the dying of adult worker bees a consequence of short telomeres and premature aging?

作者: Reinhard Stindl , Wolfgang Stindl

DOI: 10.1016/J.MEHY.2010.04.003

关键词:

摘要: Einstein is often quoted to have said that without the bee, mankind would but 4years live. It highly unlikely he made this comment, which was even mentioned in a Lancet article on honey bees. However, current vanishing of bees can serious consequences for human health, because 35% diet thought benefit from pollination. Colony collapse disorder (CCD) characterized by rapid decline adult bee population, leaving brood and queen poorly or completely unattended, with no dead bodies around hive. A large study found evidence presence amount any individual pesticide infectious agent occurred more frequently abundantly CCD-affected colonies. The growing consensus are suffering comprised immune systems, allow various pathogens invade. question remains, what causes immunosuppression many colonies Apis mellifera North America Europe? Telomeres protective DNA structures located at eukaryotic chromosome tips shorten somatic tissues animals age. Lifelong tissue regeneration takes place mellifera, worker been shown senesce. In humans, vast literature has accumulated exhausted telomere reserves causing impaired age-associated diseases, specifically cancer immunosuppression. Therefore, we propose new causative mechanism bees: critically short telomeres long-lived winter We term premature aging syndrome.

参考文章(37)
Shippen De, Fitzgerald Ms, McKnight Td, Plant telomeres and telomerases. A review. Biochemistry. ,vol. 62, pp. 1224- 1231 ,(1997)
Jerry W. Shay, Woodring E. Wright, Hayflick, his limit, and cellular ageing Nature Reviews Molecular Cell Biology. ,vol. 1, pp. 72- 76 ,(2000) , 10.1038/35036093
Ken Sahara, František Marec, Walther Traut, TTAGG Telomeric Repeats in Chromosomes of Some Insects and Other Arthropods Chromosome Research. ,vol. 7, pp. 449- 460 ,(1999) , 10.1023/A:1009297729547
Stig W Omholt, Gro V Amdam, Epigenetic Regulation of Aging in Honeybee Workers Science of Aging Knowledge Environment. ,vol. 2004, pp. pe28- pe28 ,(2004) , 10.1126/SAGEKE.2004.26.PE28
R. M. Johnson, J. D. Evans, G. E. Robinson, M. R. Berenbaum, Changes in transcript abundance relating to colony collapse disorder in honey bees (Apis mellifera). Proceedings of the National Academy of Sciences of the United States of America. ,vol. 106, pp. 14790- 14795 ,(2009) , 10.1073/PNAS.0906970106
Jesper Graakjaer, JA LONDONO‐VALLEJO, Kaare Christensen, Steen Kølvraa, The pattern of chromosome-specific variations in telomere length in humans shows signs of heritability and is maintained through life. Annals of the New York Academy of Sciences. ,vol. 1067, pp. 311- 316 ,(2006) , 10.1196/ANNALS.1354.042
Reinhard Stindl, Is telomere erosion a mechanism of species extinction Journal of Experimental Zoology. ,vol. 302, pp. 111- 120 ,(2004) , 10.1002/JEZ.B.20006
Michael W. Nachman, Jeremy B. Searle, Why is the house mouse karyotype so variable Trends in Ecology and Evolution. ,vol. 10, pp. 397- 402 ,(1995) , 10.1016/S0169-5347(00)89155-7
M. E. Scharf, D. Wu-Scharf, X. Zhou, B. R. Pittendrigh, G. W. Bennett, Gene expression profiles among immature and adult reproductive castes of the termite Reticulitermes flavipes. Insect Molecular Biology. ,vol. 14, pp. 31- 44 ,(2005) , 10.1111/J.1365-2583.2004.00527.X