Longitudinal decline in speech production in Parkinson's disease spectrum disorders
作者： Sharon Ash , Charles Jester , Collin York , Olga L. Kofman , Rachel Langey
DOI: 10.1016/J.BANDL.2017.05.001
关键词:
摘要: We examined narrative speech production longitudinally in non-demented (n=15) and mildly demented (n=8) patients with Parkinson's disease spectrum disorder (PDSD), we related increasing impairment to structural brain changes specific language motor regions. Patients provided semi-structured samples, describing a standardized picture at two time points (mean±SD interval=38±24months). The recorded samples were analyzed for fluency, grammar, informativeness. PDSD dementia exhibited significant decline their speech, unrelated overall cognitive or functioning. Regression analysis subset of MRI scans (n=11) revealed that impaired performance Time 2 was associated reduced gray matter (GM) volume 1 regions interest important functioning but not GM areas. These results dissociate systems highlight the importance non-motor declining PDSD.
sci-hub.se 参考文章(67)
Kellogg W. Hunt, Grammatical structures written at three grade levels National Council of Teachers of English. ,(1965)
Kelly A. Gola, Avril Thorne, Lisa D. Veldhuisen, Cordula M. Felix, Sarah Hankinson, Julie Pham, Tal Shany-Ur, Guido P. Schauer, Christine M. Stanley, Shenly Glenn, Bruce L. Miller, Katherine P. Rankin, Neural substrates of spontaneous narrative production in focal neurodegenerative disease Neuropsychologia. ,vol. 79, pp. 158- 171 ,(2015) , 10.1016/J.NEUROPSYCHOLOGIA.2015.10.022
Emiliano Zaccarella, Lars Meyer, Michiru Makuuchi, Angela D. Friederici, Building by Syntax: The Neural Basis of Minimal Linguistic Structures Cerebral Cortex. ,vol. 27, pp. 411- 421 ,(2015) , 10.1093/CERCOR/BHV234
Miyako Oguru, Hisao Tachibana, Kazuo Toda, Bungo Okuda, Nobuyuki Oka, Apathy and depression in Parkinson disease. Journal of Geriatric Psychiatry and Neurology. ,vol. 23, pp. 35- 41 ,(2010) , 10.1177/0891988709351834
St Heim, B Opitz, A.D Friederici, Distributed cortical networks for syntax processing: Broca’s area as the common denominator Brain and Language. ,vol. 85, pp. 402- 408 ,(2003) , 10.1016/S0093-934X(03)00068-3
Dag Aarsland, Kjeld Andersen, Jan P. Larsen, Anette Lolk, Prevalence and Characteristics of Dementia in Parkinson Disease Archives of Neurology. ,vol. 60, pp. 387- 392 ,(2003) , 10.1001/ARCHNEUR.60.3.387
B AVANTS, C EPSTEIN, M GROSSMAN, J GEE, Symmetric diffeomorphic image registration with cross-correlation: evaluating automated labeling of elderly and neurodegenerative brain. Medical Image Analysis. ,vol. 12, pp. 26- 41 ,(2008) , 10.1016/J.MEDIA.2007.06.004
J. L. Cummings, A. Darkins, M. Mendez, M. A. Hill, D. F. Benson, Alzheimer's disease and Parkinson's disease: Comparison of speech and language alterations Neurology. ,vol. 38, pp. 680- 680 ,(1988) , 10.1212/WNL.38.5.680
Daniel B. Hier, Karen Hagenlocker, Andrea Gellin Shindler, Language disintegration in dementia: Effects of etiology and severity ☆ Brain and Language. ,vol. 25, pp. 117- 133 ,(1985) , 10.1016/0093-934X(85)90124-5
Murray Grossman, Susan Carvell, Matthew B. Stern, Stephen Gollomp, Howard I. Hurtig, Sentence comprehension in Parkinson's disease: The role of attention and memory Brain and Language. ,vol. 42, pp. 347- 384 ,(1992) , 10.1016/0093-934X(92)90074-O