Development of a nanoprecipitation method for the entrapment of a very water soluble drug into Eudragit RL nanoparticles.

摘要: Rivastigmine hydrogen tartrate (RHT), one of the potential cholinesterase inhibitors, has received great attention as a new drug candidate for treatment Alzheimer's disease. However, bioavailability RHT from conventional pharmaceutical forms is low because presence blood brain barrier. The main aim present study was to prepare positively charged Eudragit RL 100 nanoparticles model scaffold providing sustained release profile RHT. formulations were evaluated in terms particle size, zeta potential, surface morphology, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC). Drug entrapment efficiency vitro properties lyophilized also examined. resulting found be size range 118 nm 154 positive (+22.5 30 mV). Nanoparticles showed 38.40 ± 8.94 62.00 2.78%. An increase mean observed with an amount polymer. FTIR, XRD, DSC results ruled out any chemical interaction between RL100 containing ratio polymer (4:1) presented faster on contrary, high (10:1) able give more drug. revealed that capable releasing prolonged period time increasing bioavailability.