Metabolic Profiles in Children During Fasting

摘要: BACKGROUND: Hypoglycemia is one of the most common metabolic derangements in childhood. To establish cause hypoglycemia, fasting tolerance tests can be used. Currently available reference values for have limitations their use daily practice. OBJECTIVE: The aim this study was to determine metabolites involved glucose homeostasis during healthy children. METHODS: This included a retrospective analysis 488 tests. All patients (n = 321) with disorders, including and endocrine were excluded, as performed children who over- or underweight. RESULTS: In 167 study, hypoglycemia reached 52 (31%) On basis time until reached, 3 age groups could defined: (1) aged 0 24 months (median 15 months) 49); (2) 25 84 45 79); (3) 85 216 106 39). all groups, significant increase ketone body levels decrease plasma observed fasting. Younger had faster than older CONCLUSIONS: Reference generated. Those used whether child has normal response. For high-risk children, guidelines concerning maximum dietary intervention illness are utmost importance.