Malignant neoplasms of decidual origin (deciduosarcomas) induced by estrogen-progestin-releasing intravaginal devices in rabbits.
作者： I Spiro , R Hertz , B C Zook
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摘要: A combination of estrogen and levonorgestrel was continuously delivered to 23 adult rabbits for up 2 years via a Silastic ring device sutured into the vagina. Twenty-one control were given similar rings devoid drugs. marked decidual reaction endometrium occurred in 16 test rabbits. In 14 (61%) malignant tumors developed type cells not heretofore described. The deciduosarcomas composed anaplastic that invaded uterine walls, lymphatics, 4 13 (31%) survived treatment, metastasized lungs. Several appeared arise within spleen or other abdominal organs. Other drug-related lesions included vaginal polyps, endometrial atrophy, focal necrosis mineralization wall. Cells from several failed produce nude mice colonize on soft agar. No decidualization neoplasms seen controls.
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