Testing anxiolytic drugs in the C57BL/6J mouse strain.

摘要: Abstract C57BL/6J mice are one of the most commonly used mouse strains in biobehavioral and psychopharmacological research. Prone to variance due multiple environmental factors, animal neurophenotyping studies rely on using proper experimental protocols, study designs well-established models tests. Choosing dose range for anxiolytic or anxiogenic drugs is key obtaining valid testing results correct data interpretation. Here we emphasize importance accurate selection rodent anxiety paradigms concluding whether strain “sensitive” therefore appropriate studying selected behavioral We also provide further argument support compounds.