Hypothesis: Human Umbilical Cord Blood-Derived Stromal Cells Regulate the Foxp3 Expression of Regulatory T Cells Through the TGF-β1/Smad3 Pathway

摘要: Despite the improvements in transplant immunology and clinical supportive care, graft-versus-host disease (GVHD) is still among most common causes of overall mortality morbidity after allogeneic hematopoietic cell transplantation. The development severity GVHD are strongly related with post-transplant outcomes. New strategies should be explored to overcome GVHD. Regulatory T cells (Treg cells), as dedicated suppressors diverse immune responses inflammation important gatekeepers homeostasis, contribute prevention graft rejection induce transplantation tolerance. Foxp3, a transcription factor, predominantly expressed Treg master regulator function cells. Foxp3 mutations deficiency lead lethal autoimmune lymphoproliferative disease, which results from defect TGF-β1 required maintain expression We isolated novel population CD34+ our laboratory, referred human umbilical cord blood-derived stromal (hUCBDSCs), exert an immunosuppressive effect can notably increase Our previous study also revealed that hUCBDSCs constantly secrete TGF-β1. Based on literature searchings experimental findings, we hypothesize hUCBDSCs, high level TGF-β1, modulate through TGF-β1/Smad3 pathway regulate