Continuous infusion of spinally administered narcotics for the relief of pain due to malignant disorders

作者: Elliot S. Krames , Jay Gershow , Alan Glassberg , Thomas Kenefick , Arthur Lyons

DOI: 10.1002/1097-0142(19850801)56:3<696::AID-CNCR2820560343>3.0.CO;2-8

关键词:

摘要: The INFUSAID model #400 totally implantable drug delivery system was implanted in 17 patients for the continuous infusion of spinally administered preservative-free morphine sulfate. Sixteen had pain malignant origin, and one patient secondary to meningomyelocele. Over time, there a consistent mean improvement analgesia scores ranging from 50% 70% control levels 16 with cancer-related pain. This form therapy not successful treating benign Overall, cancer were pleased their therapy, experienced few complications, reported improved quality life. Continuous narcotics using such as is safe, complication-free procedure

参考文章(20)
Robert E. Harbaugh, Dennis W. Coombs, Richard L. Saunders, Michael Gaylor, Mark Pageau, Implanted continuous epidural morphine infusion system. Preliminary report. Journal of Neurosurgery. ,vol. 56, pp. 803- 806 ,(1982) , 10.3171/JNS.1982.56.6.0803
C. B. Pert, G. Pasternak, S. H. Snyder, Opiate Agonists and Antagonists Discriminated by Receptor Binding in Brain Science. ,vol. 182, pp. 1359- 1361 ,(1973) , 10.1126/SCIENCE.182.4119.1359
J. Hughes, T. W. Smith, H. W. Kosterlitz, Linda A. Fothergill, B. A. Morgan, H. R. Morris, Identification of two related pentapeptides from the brain with potent opiate agonist activity Nature. ,vol. 258, pp. 577- 579 ,(1975) , 10.1038/258577A0
Tony L. Yaksh, Analgetic actions of intrathecal opiates in cat and primate. Brain Research. ,vol. 153, pp. 205- 210 ,(1978) , 10.1016/0006-8993(78)91146-0
Jane Scott, E. C. Huskisson, Graphic representation of pain. Pain. ,vol. 2, pp. 175- 184 ,(1976) , 10.1016/0304-3959(76)90113-5
Michael A. Beaven, Anaphylactoid reactions to anesthetic drugs. Anesthesiology. ,vol. 55, pp. 3- 5 ,(1981) , 10.1097/00000542-198107000-00002
Lars Terenius, Agneta Wahlström, Morphine-like ligand for opiate receptors in human CSF Life Sciences. ,vol. 16, pp. 1759- 1764 ,(1975) , 10.1016/0024-3205(75)90269-6
Mark S. Gold, Opiate Withdrawal Using Clonidine JAMA. ,vol. 243, pp. 343- 346 ,(1980) , 10.1001/JAMA.1980.03300300021018