Challenges in the Diagnosis and Management of Growth Hormone Deficiency in India.

作者: Mathew John , Ekaterina Koledova , Kanakatte Mylariah Prasanna Kumar , Harshal Chaudhari

DOI: 10.1155/2016/2967578

关键词:

摘要: In clinical practice, every year approximately 150,000 children are referred with short stature (SS) based on a cut-off of fifth percentile. The most important endocrine and treatable cause SS is growth hormone deficiency (GHD). lack reliable data the prevalence GHD in India limits estimation magnitude this problem. diagnosis treatment hurdled various challenges, restricting availability (GH) therapy to only very limited segment India. This review will firstly summarize gaps challenges literature analysis. Subsequently, it presents suggestions from members at advisory board meetings overcome these challenges. suggested that early initiation could better chances achieving final adult height within normal range for population. Education awareness about disorders among parents, regular training physicians, more emphasis using Indian charts monitoring would help improve GHD. Availability an easy-to-use delivery system also be beneficial improving adherence satisfactory outcomes.

参考文章(65)
Benjamin U. Nwosu, Mary M. Lee, Evaluation of short and tall stature in children. American Family Physician. ,vol. 78, pp. 597- 604 ,(2008)
R Mittal, S Rai, S K Upadhyay, K N Agarwal, D K Agarwal, R Prakash, Physical and sexual growth pattern of affluent Indian children from 5 to 18 years of age. Indian Pediatrics. ,vol. 29, pp. 1203- 1282 ,(1992)
San-Ging Shu, Ching-Shiang Chi, Yu-Dan Chen, Clinical evaluation of short children referred by school screening: an analysis of 655 children. Acta paediatrica Taiwanica. ,vol. 43, pp. 340- 344 ,(2002)
P. S. N. Menon, P. G. Gopinath, Anju Virmani, A. K. Padhy, M. G. Karmarkar, Profile of thyroid disorders in a referral centre in north India. Indian Pediatrics. ,vol. 26, pp. 265- 269 ,(1989)
VamanV Khadilkar, AnuradhaV Khadilkar, Revised Indian Academy of Pediatrics 2015 growth charts for height, weight and body mass index for 5-18-year-old Indian children Indian Journal of Endocrinology and Metabolism. ,vol. 19, pp. 470- 476 ,(2015) , 10.4103/2230-8210.159028
Madhulika Kabra, Anurag Bajpai, Arun Kumar Gupta, P S N Menon, Growth pattern and skeletal maturation following growth hormone therapy in growth hormone deficiency: factors influencing outcome. Indian Pediatrics. ,vol. 43, pp. 593- 599 ,(2006)
Z. A. Efstathiadou, A. Bargiota, A. Chrisoulidou, G. Kanakis, L. Papanastasiou, A. Theodoropoulou, S. K. Tigas, D. A. Vassiliadi, M. Alevizaki, S. Tsagarakis, Impact of gsp mutations in somatotroph pituitary adenomas on growth hormone response to somatostatin analogs: a meta-analysis Pituitary. ,vol. 18, pp. 861- 867 ,(2015) , 10.1007/S11102-015-0662-5
Ayman A. Zayed, Moaath K. Mustafa Ali, Mohammad A. Al-Ani, Munther S. Momani, Al-Motassem F. Yousef, The prevalence of isolated growth hormone deficiency among children of short stature in Jordan and its relationship with consanguinity Clinical Endocrinology. ,vol. 81, pp. 876- 882 ,(2014) , 10.1111/CEN.12510
Morey Haymond, Anne-Marie Kappelgaard, Paul Czernichow, Beverly MK Biller, Koji Takano, Wieland Kiess, , Early recognition of growth abnormalities permitting early intervention Acta Paediatrica. ,vol. 102, pp. 787- 796 ,(2013) , 10.1111/APA.12266
D T Wyatt, D Mark, A Slyper, Survey of growth hormone treatment practices by 251 pediatric endocrinologists. The Journal of Clinical Endocrinology and Metabolism. ,vol. 80, pp. 3292- 3297 ,(1995) , 10.1210/JCEM.80.11.7593441