Striatal and Extrastriatal Dopamine D2/D3 Receptors in Schizophrenia Evaluated With [18F]fallypride Positron Emission Tomography

摘要: positron emission tomography with [ 18 F]fallypride to evaluate D2/D3 receptors in both striatal and extrastriatal regions schizophrenia. Methods: Twenty-one patients schizophrenia 22 matched healthy control subjects were scanned an ECAT EXACT HRcamera. Two-tissue compartment modeling the reference tissue method gave binding potentials relative nondisplaceable uptake, total plasma concentration, free concentration. These compared between groups five eight regions. Several regional volumes lower patient group, data corrected for partial volume effects. Results: Bindingpotentialvaluesdifferedinthreeregionsbetweengroups.Valuesforbindingpotentialrelativetonondisplaceableuptake from two-tissue subjects, respectively, 28.7 6.8 25.3 4.3 postcommissural caudate, 2.9 .7 2.6 .4 thalamus, 1.8 .5 2.1 uncus. Loss of age was found greater neocortex. Conclusions: Our study selective alterations regions, consistent some but not all previously published reports. As shown striatum, a more sensitive imaging approach studying role dopamine pathophysiology might be assessment neurotransmitter levels rather than D2/D3receptor