摘要: Proteins mediate transmission of signals along intercellular and intracellular pathways between the exterior interior a cell. The dynamic properties signaling proteins are crucial to their functions. We discuss emerging paradigms for role protein dynamics in signaling. A central tenet is that fluctuate among many states on evolutionarily selected energy landscapes. Upstream remodel this landscape, causing transmit information downstream partners. New methods provide insight into at atomic scale. next stages hierarchy-how multiple integrated how cellular organized space time-present exciting challenges future, requiring bold multidisciplinary approaches.
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