Age-differential association between serum uric acid and incident hypertension

摘要: Increasing evidence suggests a positive association between the serum uric acid (SUA) level and incident hypertension. However, has been inconsistent based on age, sex, body mass index, lipid profiles. Thus, we investigated whether there is an interaction SUA other risk factors hypertension in Korean general population. In this study, 808 participants aged 40-79 years were included. They free of major cardiovascular disease at baseline. Incident was defined as systolic blood pressure (SBP) ≥ 140 mmHg, diastolic (DBP) ≥ 90 mmHg, or use antihypertensive medication. To investigate modified by for hypertension, generalized linear model Z test used. During mean follow-up 3.3 years, 11.5% men 10.7% women developed The according to participant age (p interaction = 0.009). positively significant among people aged < 55 (relative 1.74 per 1.0 mg/dL SUA; p = 0.002), but no aged ≥ 55 (p = 0.894). secondary analysis, not associated with increase SBP, DBP. We observed age-differential Koreans. An increased can be trigger through early vascular changes middle-aged