The Fundamental Role of Melanocortins in Brain Processes
作者： V. Klusa , B. Jansone , S. Svirskis , J. Rumaks , R. Muceniece
DOI: 10.1007/978-94-007-0958-4_21
关键词:
摘要: The discoveries of the latest ten years have shed new light in understanding roles melanocortins and their receptors brain functions development different pathologies. Since 1992 when genes encoded melanocortin receptor five subtypes were identified, cloned characterized, molecular mechanisms underlying effects such as skin darkening, behaviour, food intake, anti-inflammatory action, analgesia been clarified. contribution physiological control organism homeostasis has become background for search agonists antagonists separate subtypes, that can be targeted to used therapeutic drugs treatment psychoneuroendocrine immune system diseases.
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Chhajlani, Distribution of cDNA for melanocortin receptor subtypes in human tissues. Iubmb Life. ,vol. 38, pp. 73- 80 ,(1996)
D Harbour-McMenamin, EM Smith, JE Blalock, Peptide hormones shared by the neuroendocrine and immunologic systems. Journal of Immunology. ,vol. 135, pp. 858- 861 ,(1985)
Ilona Mandrika, Ruta Muceniece, Jarl E.S Wikberg, Effects of melanocortin peptides on lipopolysaccharide/interferon-gamma-induced NF-kappaB DNA binding and nitric oxide production in macrophage-like RAW 264.7 cells: Biochemical Pharmacology. ,vol. 61, pp. 613- 621 ,(2001) , 10.1016/S0006-2952(00)00583-9
Yvon C. Chagnon, Wen-Ji Chen, Louis Pérusse, Monique Chagnon, André Nadeau, William O. Wilkison, Claude Bouchard, Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the Québec Family Study. Molecular Medicine. ,vol. 3, pp. 663- 673 ,(1997) , 10.1007/BF03401705
A.N. Eberle, The Melanotropins: Chemistry, Physiology and Mechanisms of Action ,(1988)
Y. Konda, I. Gantz, J. DelValle, Y. Shimoto, H. Miwa, T. Yamada, Interaction of dual intracellular signaling pathways activated by the melanocortin-3 receptor Journal of Biological Chemistry. ,vol. 269, pp. 13162- 13166 ,(1994) , 10.1016/S0021-9258(17)36813-8
Kit Yue Wong, Nilum Rajora, Giovanni Boccoli, Anna Catania, James M. Lipton, A potential mechanism of local anti-inflammatory action of alpha-melanocyte-stimulating hormone within the brain: modulation of tumor necrosis factor-alpha production by human astrocytic cells. Neuroimmunomodulation. ,vol. 4, pp. 37- 41 ,(1997) , 10.1159/000097313
I. Gantz, Y. Konda, T. Tashiro, Y. Shimoto, H. Miwa, G. Munzert, S.J. Watson, J. DelValle, T. Yamada, Molecular cloning of a novel melanocortin receptor. Journal of Biological Chemistry. ,vol. 268, pp. 8246- 8250 ,(1993) , 10.1016/S0021-9258(18)53088-X
D De Wied, J Jolles, Neuropeptides derived from pro-opiocortin: behavioral, physiological, and neurochemical effects. Physiological Reviews. ,vol. 62, pp. 976- 1059 ,(1982) , 10.1152/PHYSREV.1982.62.3.976
Helgi B Schiöth, The physiological role of melanocortin receptors. Vitamins and Hormones Series. ,vol. 63, pp. 195- 232 ,(2001) , 10.1016/S0083-6729(01)63007-3