Impacts of an opioid overdose prevention intervention delivered subsequent to acute care

摘要: Background Opioid overdose is a major and increasing cause of injury death. There an urgent need for interventions to reduce events among high-risk persons. Methods Adults at elevated risk opioid involving heroin or pharmaceutical opioids who had been cared in emergency department (ED) were randomised education combined with brief behavioural intervention take-home naloxone usual care. Outcomes included: (1) time first overdose-related event resulting medical attention death using competing risks survival analysis; (2) ED visit hospitalisation rates, negative binomial regression adjusting risk. Results During the follow-up period, 24% 241 participants least one event, 85% more visits 55% hospitalisation, no significant differences between comparison groups. The instantaneous was not significantly lower group (sub-HR: 0.83; 95% CI 0.49 1.40). Discussion These null findings may be due part severity population terms housing insecurity (70% impermanently housed), drug use, unemployment acute healthcare issues. Given high utilisation intensive interventions, such as direct referral provision agonist treatment medications, necessary have substantial impact on overdoses this high-acuity care settings. Trial registration number NCT0178830; Results.