Effect of dose and dose schedule on the response of intracranial pressure to mannitol.

摘要: Analysis of monitoring records 150 patients given over 1000 infusions 20% mannitol delineared three variables affecting the response intracranial pressure (ICP) to mannitol: original ICP; current dose; and dose preceding hours. The level ICP influenced as much amount mannitol; giving more than was required bring below 25 mm Hg led need for larger following doses. One hundred-milliliter-bolus doses were often effective results suggest that control increased should be kept small possible.