Observations of measles virus infection of human cells: III. Correlation of properties of clones of H.Ep.-2 cells with their susceptibility to infection☆

摘要: Abstract Clonal strains of human epidermoid carcinoma No. 2 cells have been isolated that differ from one another in morphology and nutritional requirements. The also their response to infection with measles virus. One line produced more than 10,000 times as much virus some other lines. number particles essential for initiating the various clones differed by a thousandfold, insusceptibility was correlated delayed appearance cytopathic effect. qualitatively among several clonal types. It found possible synchronize cell division clone exhibiting shortest generation time. Attempts slower-growing cultures were unsuccessful. has synchronized is most sensitive Finally, there appears be correlation between time, time required response, amount 7 days after infection.