Molecular targets and anticancer potential of sanguinarine—a benzophenanthridine alkaloid

摘要: Abstract Background Cancer is an enormous global health burden, and should be effectively addressed with better therapeutic strategies. Currently, over 60% of the clinically approved anticancer agents are either directly isolated from natural sources or modified lead molecules. Sanguinarine (SNG), a quaternary benzophenanthridine alkaloid has gained increasing attention in recent years as potential agent. Purpose There large untapped source phytochemical-based remaining to explored. This review article aims recapitulate different properties SNG, describes some molecular targets involved exerting its effect. It also depicts pharmacokinetic toxicological two parameters important determining druggability molecule. Methods Numerous vivo vitro published studies have signified SNG. In order collate decipher these properties, extensive literature search was conducted PubMed, ScienceDirect, Scopus using keywords followed by evaluation relevant articles where reports integrated analyzed. Results Apart inducing cell death, SNG inhibits pro-tumorigenic processes such invasion, angiogenesis, metastasis cancers. Moreover, been shown synergistically enhance sensitivity several chemotherapeutic effective against variety multi-drug resistant