Application of imaging based tools for the characterisation of hollow spray dried amorphous dispersion particles.

摘要: Abstract The aim of this study was to investigate novel approaches determine spray dried dispersion (SDD) specific particle characteristics through the use imaging based technologies. work demonstrates that can be applied in order access quantitative approximations for powder hollow particles, such as SDD. Cryo-SEM has been used measure solid volume fraction and/or density SDD particles. Application data understand impact drying process conditions on properties, and their processability final dosage form quality were investigated. from a Morphologi G3 image characterisation system also examined explain both propensity extent attrition within series samples, demonstrate light transmission assess relative wall thickness Such means potentially useful information linked important materials which, addition standard bulk measurements density, may enable better understanding downstream acceptability.