Effect of treatment with the nonsteroidal antiinflammatory meloxicam on milk production, somatic cell count, probability of re-treatment, and culling of dairy cows with mild clinical mastitis

摘要: It was hypothesized that treatment of clinical mastitis with a combination nonsteroidal antiinflammatory (meloxicam) and parenteral antibiotic (penethamate hydriodide) would result in lower somatic cell counts (SCC), reduced milk yield losses, improved outcomes, culling rates compared therapy alone. Cows 15 herds during the first 200 d lactation (median = 13 d) were treated 5 g penethamate hydriodide daily for 3 d, one-half these cows 250 mg drug meloxicam (n 361 cows), whereas other half 366 cows) vehicle (control group). Milk samples bacteriology collected from clinically affected glands before treatment, at 7 (+/-3), 14 21 (+/-3) after commencement SCC determination. Additionally, rectal temperature, udder edema score, California Mastitis Test clot score determined data across lactation. There no differences between groups calving date, days milk, age, breed, or bacterial pathogens isolated treatment. difference number defined as failures (i.e., re-treated within 24 initial died, gland stopped producing milk); 79 (21.9%) vs. 92 (25.1%) control failed, respectively. The meloxicam-treated group [550 +/- 48 711 62 geometric mean (x1,000/mL) standard error quarters control, respectively]. 28 Fewer than removed (culled) [39/237 (16.4%) 67/237 (28.2%) cows, respectively; odds ratio 0.42, 95% confidence interval 0.26 to 0.68]. concluded resulted risk removal herd (culling)