Snail Is a Direct Target of Hypoxia-inducible Factor 1α (HIF1α) in Hypoxia-induced Endothelial to Mesenchymal Transition of Human Coronary Endothelial Cells.

摘要: Endothelial to mesenchymal transition (EndMT) was originally described in heart development where the endocardial endothelial cells that line atrioventricular canal undergo an EndMT form cushion later gives rise septum and mitral tricuspid valves. In postnatal specifically, originate from endocardium maintain increased susceptibility as remnants their embryonic origin. Such involving adult coronary contributes microvascular rarefaction subsequent chronification of hypoxia injured heart, ultimately leading cardiac fibrosis. Although most beds induces tip cell formation sprouting angiogenesis, here we demonstrate is a stimulus for human phenotypic changes reminiscent via mechanism hypoxia-inducible factor 1α-induced activation master regulatory transcription SNAIL. Our study adds further evidence unique endocardium-derived provides novel insights into how progression Additional studies may be required discriminate between distinct angiogenesis responses different populations.