Studies on Veratrum alkaloids. XXVIII. The action of the erythrophleum alkaloids on the single twitch and on the veratrine response of the sartorius muscle of the frog.

摘要: The antiveratrinic activity of a series erythrophleum alkaloids was examined in the isolated sartorius muscle frog. All studied were active. As with cardiac glycosides potency antagonizing effect given concentration veratridine skeletal paralleled closely their positive intropic vertebrate heart. This parallelism extended also to synthetic ester, dimethylaminoethanol pimelate, which differs from native only acid involved, and breakdown products. type these is similar that glycosides. In both cases pretreatment does not prevent appearance transient veratrine response. development depends upon muscle. duration influence time course action. typical therefore independent process diffusion site