Five day moxifloxacin therapy compared with 7 day clarithromycin therapy for the treatment of acute exacerbations of chronic bronchitis

摘要: In this multinational, randomized, double-blind study, the efficacy and safety of a 5 day course moxifloxacin 400 mg orally od was compared with that 7 clarithromycin 500 bd. in 750 patients acute exacerbations chronic bronchitis, characterized by at least two symptoms: sputum purulence, increased volume or dyspnoea. Seven days after end therapy, clinical cure achieved for 89% (287 322) efficacy-evaluable group 88% (289 327) (95% CI, -3.9%, 5.8%). At follow-up (21-28 post-treatment), continued rates were (256 287) (257 289) clarithromycin. A total 342 pathogenic bacteria isolated from 287 patients. The most common pathogens Haemophilus influenzae (37%), Streptococcus pneumoniae (31%) Moraxella catarrhalis (18%). post-treatment, successful bacteriological response obtained 77% (89 115) 62% (71 114) group, indicating superiority 3.6%, 26.9%). Both treatments well tolerated few adverse events. This study demonstrated treatment bronchitis clinically equivalent bacteriologically superior to