Application of polarography and voltammetry to drug analysis in industry.

摘要: Essential to the renewal of interest in polarography and voltammetry 1970s were availability reliable polarographs offering pulse mode, with sensitivity down lo-‘-lo-* M h’gh 1 er resolving power; a better understanding electrode processes compounds pharmaceutical (active agents, excipients, additives, antioxidants, etc.); application oxidation waves, making technique available wide range pharmaceuticals. Davidson [l] has surveyed use voltammetric oxidative mode. Few modern books [2-41 but several recent review articles [5-101 discuss electrochemistry (polarography voltammetry) drugs. According Fogg [ll] answer question: “Voltammetry, is it worth considering?” an emphatic “yes” for determination drugs biological materials. VirC Patriarche [12] comment: “ . among modem analytical techniques differential sciences well justified regard accuracy sensitivity, shown be rapid investigation complex media .” they conclude: “it reasonable think that this will applied more analysis future.” The literature last few years shows are particularly chemistry. USP XX quotes 16 formulations assayed by polarography. Does all activity mean are, or be, used industry? Osteryoung [13] note “The electroanalytical methods industry obviously depends on individuals knowledgeable area, applicability solve real problems, instrument available. ” One main objections advanced analysts both purely academic; mostly encountered basic electrochemical courses. Both demanding than most other instrumental industrial laboratories 113-17, 681, practised